BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//EPIC Emerging & Pandemic Infections Consortium - ECPv6.15.11//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:EPIC Emerging & Pandemic Infections Consortium
X-ORIGINAL-URL:https://epic.utoronto.ca
X-WR-CALDESC:Events for EPIC Emerging & Pandemic Infections Consortium
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Toronto
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20250309T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20251102T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20260308T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20261101T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20270314T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20271107T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20260504T093000
DTEND;TZID=America/Toronto:20260504T103000
DTSTAMP:20260429T100555
CREATED:20260428T193641Z
LAST-MODIFIED:20260428T193641Z
UID:7710-1777887000-1777890600@epic.utoronto.ca
SUMMARY:Damage‑triggered calcium signaling: How LLO activates PGE₂ pathways to license T‑Cell immunity
DESCRIPTION:Join the Department of Molecular Genetics for a special seminar hosted by EPIC member John Brumell with John-Demian Sauer who is a Professor of Medical Microbiology & Immunology at the University of Wisconsin-Madison. \nSauer will be giving a talk titled “Damage‑triggered calcium signaling: How LLO activates PGE₂ pathways to license T‑Cell immunity”. Please see the abstract below for more details: \nAbstract: Recognition of invading pathogens by the innate immune system triggers a series of signaling cascades that together program appropriate adaptive immune responses. Listeria monocytogenes is a Gram positive\, intracellular pathogen that triggers robust cytosolic innate immune responses upon expression of the bacterial pore forming toxin Listeriolysin O (LLO) and subsequent escape from the phagosome into the host cell cytosol. For decades it has been known that escape from the phagosome by L. monocytogenes is essential for priming of a robust protective immune response mediated by CD8+ T-cells however\, what specific responses in the cytosol help promote T-cell priming has remained unknown. We recently demonstrated that production of the eicosanoid prostaglandin E2 following L. monocytogenes infection is essential for optimal CD8+ T-cell priming. We additionally demonstrated that L. monocytogenes expression of LLO is essential for PGE2 production and that phagocytes are the primary producers of PGE2 during L. monocytogenes infection in vivo. Through a series of ex vivo experiments in primary bone marrow derived macrophages we found that the function of LLO in PGE2 induction is to trigger a phagosome dependent Ca2+ flux from the Listeria containing phagosome that\, in combination with ERK2 signaling\, ultimately activates the cytosolic phospholipase cPLA2. Activation of cPLA2 releases arachidonic acid from the membrane allowing for the COX-2 and mPGES-1 production of PGE2. How phagocyte production of PGE2 promotes T-cell priming and how we can harness this to improve Listeria-based anti-cancer vaccines are ongoing areas of study. \nDate: 4 May\, 2026 \nTime: 9:30 – 10:30 a.m. \nLocation: Event room 1\, Peter Gilgan Centre for Research and Learning\, The Hospital for Sick Children \nRegistration is not required. 
URL:https://epic.utoronto.ca/event/damage%e2%80%91triggered-calcium-signaling-how-llo-activates-pge%e2%82%82-pathways-to-license-t%e2%80%91cell-immunity/
LOCATION:PGCRL Event Room 1\, 686 Bay Street\, Toronto\, ON\, Canada
CATEGORIES:In-person,Seminar
ATTACH;FMTTYPE=application/pdf:https://epic.utoronto.ca/wp-content/uploads/2026/04/John-Demian-Sauer-Poster.pdf
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20260504T130000
DTEND;TZID=America/Toronto:20260504T140000
DTSTAMP:20260429T100555
CREATED:20260428T194936Z
LAST-MODIFIED:20260428T194936Z
UID:7714-1777899600-1777903200@epic.utoronto.ca
SUMMARY:Listeria promotes systemic infection by targeting the host deubiquitinase CYLD
DESCRIPTION:Join the Department of Molecular Genetics for the PhD Defence of Dustin Ammendolia\, who is supervised by EPIC member John Brumell. \nDustin will be presenting his thesis work titled “Listeria promotes systemic infection by targeting the host deubiquitinase CYLD.” \nDate: 4 May 2026 \nTime: 1:00 – 2:00 p.m. \nLocation: Room 03-14-012B\, Patient Support Centre\, The Hospital for Sick Children and online \nOnline attendance: Via Zoom\n• Meeting ID: 625 4068 0085\n• Passcode: 253737
URL:https://epic.utoronto.ca/event/listeria-promotes-systemic-infection-by-targeting-the-host-deubiquitinase-cyld/
LOCATION:The Hospital for Sick Children
CATEGORIES:In-person,Seminar
ATTACH;FMTTYPE=application/pdf:https://epic.utoronto.ca/wp-content/uploads/2026/04/Ammendolia-Seminar_0.pdf
END:VEVENT
END:VCALENDAR