Natasha Christie-Holmes has managed the high-containment facilities at U of T for 13 years, developing the detailed regulatory and operational program underpinning the impactful research output of the labs. Her research expertise is in the areas of molecular virology, viral evolution and the dynamics of immune escape during viral infections. In her regulatory role, she has helped the Public Health Agency of Canada develop biosafety and biosecurity regulations. During the COVID-19 pandemic, Dr. Christie-Holmes developed a core team of CL3-trained staff to support SARS-CoV-2 research. She has led several major research projects in partnership with governmental and industry collaborators, providing key insights into decontamination of SARS-CoV-2 on PPE and persistence of the virus on currency, among other findings.