A new national hub focused on enhancing Canada’s ability to respond quickly, effectively and equitably to future pandemics has become a reality with $2 million in funding from the Canada Biomedical Research Fund. Led and anchored by the University of Toronto, the Canadian Hub for Health Intelligence and Innovation in Infectious Diseases (HI3) is a collaborative, multi-disciplinary and multi-sector coalition of over 80 partners. It will provide a powerful network to support a robust domestic pipeline of life-saving vaccines and therapeutics targeting existing and emerging infectious threats.